Article-Journal

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
Abstract Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its …
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Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using …
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Virtual reality-empowered deep-learning analysis of brain cells
Abstract Automated detection of specific cells in three-dimensional datasets such as whole-brain light-sheet image stacks is …
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Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples
Abstract In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared …
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Multiplex protein imaging in tumour biology
Multiplex protein imaging advances tumor biology by revealing cellular interactions and spatial organization. This review discusses its applications, integration with spatial omics, and challenges.
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Multiplex protein imaging in tumour biology
Distinct molecular profiles of skull bone marrow in health and neurological disorders
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones …
Zeynep Ilgin Kolabas, Louis B. Kuemmerle, Robert Perneczky, Benjamin Förstera, Selin Ulukaya, Mayar Ali, Saketh Kapoor, Laura M. Bartos, Maren Büttner, Ozum Sehnaz Caliskan, Zhouyi Rong, Hongcheng Mai, Luciano Höher, Denise Jeridi, Muge Molbay, Igor Khalin, Ioannis K. Deligiannis, Moritz Negwer, Kenny Roberts, Alba Simats, Olga Carofiglio, Mihail I. Todorov, Izabela Horvath, Furkan Ozturk, Selina Hummel, Gloria Biechele, Artem Zatcepin, Marcus Unterrainer, Johannes Gnörich, Jay Roodselaar, Joshua Shrouder, Pardis Khosravani, Benjamin Tast, Lisa Richter, Laura Díaz-Marugán, Doris Kaltenecker, Laurin Lux, Ying Chen, Shan Zhao, Boris-Stephan Rauchmann, Michael Sterr, Ines Kunze, Karen Stanic, Vanessa W.Y. Kan, Simon Besson-Girard, Sabrina Katzdobler, Carla Palleis, Julia Schädler, Johannes C. Paetzold, Sabine Liebscher, Anja E. Hauser, Ozgun Gokce, Heiko Lickert, Hanno Steinke, Corinne Benakis, Christian Braun, Celia P. Martinez-Jimenez, Katharina Buerger, Nathalie L. Albert, Günter Höglinger, Johannes Levin, Christian Haass, Anna Kopczak, Martin Dichgans, Joachim Havla, Tania Kümpfel, Martin Kerschensteiner, Martina Schifferer, Mikael Simons, Arthur Liesz, Natalie Krahmer, Omer A. Bayraktar, Nicolai Franzmeier, Nikolaus Plesnila, Suheda Erener, Victor G. Puelles, Claire Delbridge, Harsharan Singh Bhatia, Farida Hellal, Markus Elsner, Ingo Bechmann, Benjamin Ondruschka, Matthias Brendel, Fabian J. Theis, Ali Erturk
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Whole-mouse clearing and imaging at the cellular level with vDISCO
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Scalable tissue labeling and clearing of intact human organs
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Cellular and Molecular Probing of Intact Human Organs
SHANEL permeabilizes aged human organs for deep 3D imaging, enabling transparency, comprehensive labeling, and rapid cell-level analysis.
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Cellular and Molecular Probing of Intact Human Organs
Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections
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