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Enantioselective syntheses and application of 4- textitepi -galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles
Efficient syntheses of 4- epi -galiellalactone and the corresponding activity-based probe enabled chemoproteomic studies to reveal the …
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Enantioselective Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids via Cope Rearrangements
Ampilectane and serrulatane natural products are structurally and stereochemically complex compounds that display various potent …
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Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis
Significance Baicalin is a major flavonoid component from the herbal medicine Scutellaria baicalensis that has been shown to have an …
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Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling
The coupling reactions of diaryltetrazoles with carboxylic acids under UV irradiation were investigated. Application of these …
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Microengineered textitin vitro model of cardiac fibrosis through modulating myofibroblast mechanotransduction
Cardiac fibrosis greatly impairs normal heart function post infarction and there is no effective anti-fibrotic drug developed at present. …
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Glycerol-Mediated Nanostructure Modification Leading to Improved Transparency of Porous Polymeric Scaffolds for High Performance 3D Cell Imaging
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Micro-scaffold array chip for upgrading cell-based high-throughput drug testing to 3D using benchtop equipment
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Multifaceted applications of nanomaterials in cell engineering and therapy
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Off-the-shelf microsponge arrays for facile and efficient construction of miniaturized 3D cellular microenvironments for versatile cell-based assays
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